About Haloacid dehalogenase-like hydrolase domain-containing protein 3
Haloacid dehalogenase-like hydrolase domain-containing protein 3 (HDHD3) is a protein
from Homo sapiens identified by UniProt accession
Q9BSH5, 251 residues long.
MolForge cross-references it against 0 known binders and
11 disease associations.
Target properties
| Protein name | Haloacid dehalogenase-like hydrolase domain-containing protein 3 |
|---|
| UniProt accession | Q9BSH5 |
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| Gene | HDHD3 |
|---|
| Organism | Homo sapiens |
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| Length | 251 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (11)
Diseases linked to this target (Open Targets).
- blood lead measurement · score 0.05
- reticulocyte count · score 0.04
- reticulocyte measurement · score 0.04
- blood protein measurement · score 0.04
- leukocyte count · score 0.03
- non-alcoholic fatty liver disease · score 0.03
- neutrophil percentage of leukocytes · score 0.02
- monocyte percentage of leukocytes · score 0.02
- colorectal cancer · score 0.00
- cancer · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BSH5-F1 | alphafold | PREDICTED | 95.66 | — |
Amino-acid sequence (251 residues)
MAHRLQIRLL TWDVKDTLLR LRHPLGEAYA TKARAHGLEV EPSALEQGFR QAYRAQSHSF PNYGLSHGLT SRQWWLDVVL QTFHLAGVQD AQAVAPIAEQ LYKDFSHPCT WQVLDGAEDT LRECRTRGLR LAVISNFDRR LEGILGGLGL REHFDFVLTS EAAGWPKPDP RIFQEALRLA HMEPVVAAHV GDNYLCDYQG PRAVGMHSFL VVGPQALDPV VRDSVPKEHI LPSLAHLLPA LDCLEGSTPG L
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