About Polycomb group RING finger protein 1
Polycomb group RING finger protein 1 (PCGF1) is a protein
from Homo sapiens identified by UniProt accession
Q9BSM1, 259 residues long.
MolForge cross-references it against 0 known binders and
84 disease associations.
Target properties
| Protein name | Polycomb group RING finger protein 1 |
|---|
| UniProt accession | Q9BSM1 |
|---|
| Gene | PCGF1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 259 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (84)
Diseases linked to this target (Open Targets).
- attention deficit hyperactivity disorder · score 0.09
- neoplasm · score 0.08
- schizophrenia 15 · score 0.07
- attention deficit-hyperactivity disorder 8 · score 0.07
- platelet crit · score 0.06
- early-onset non-syndromic cataract · score 0.06
- preeclampsia · score 0.06
- isolated ectopia lentis · score 0.06
- MODY · score 0.06
- platelet count · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BSM1-F1 | alphafold | PREDICTED | 81.76 | — |
Amino-acid sequence (259 residues)
MASPQGGQIA IAMRLRNQLQ SVYKMDPLRN EEEVRVKIKD LNEHIVCCLC AGYFVDATTI TECLHTFCKS CIVKYLQTSK YCPMCNIKIH ETQPLLNLKL DRVMQDIVYK LVPGLQDSEE KRIREFYQSR GLDRVTQPTG EEPALSNLGL PFSSFDHSKA HYYRYDEQLN LCLERLSSGK DKNKSVLQNK YVRCSVRAEV RHLRRVLCHR LMLNPQHVQL LFDNEVLPDH MTMKQIWLSR WFGKPSPLLL QYSVKEKRR
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