About EF-hand calcium-binding domain-containing protein 4B
EF-hand calcium-binding domain-containing protein 4B (CRACR2A) is a protein
from Homo sapiens identified by UniProt accession
Q9BSW2, 731 residues long.
MolForge cross-references it against 0 known binders and
54 disease associations.
Target properties
| Protein name | EF-hand calcium-binding domain-containing protein 4B |
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| UniProt accession | Q9BSW2 |
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| Gene | CRACR2A |
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| Organism | Homo sapiens |
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| Length | 731 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (54)
Diseases linked to this target (Open Targets).
- periodontitis · score 0.31
- intraocular pressure measurement · score 0.31
- bone density · score 0.30
- urate measurement · score 0.30
- metabolite measurement · score 0.10
- mean corpuscular volume · score 0.09
- mean corpuscular hemoglobin concentration · score 0.09
- glucuronate measurement · score 0.05
- mean corpuscular hemoglobin · score 0.05
- gut microbiome measurement · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BSW2-F1 | alphafold | PREDICTED | 69.30 | — |
Amino-acid sequence (731 residues)
MAAPDGRVVS RPQRLGQGSG QGPKGSGACL HPLDSLEQKE TQEQTSGQLV MLRKAQEFFQ TCDAEGKGFI ARKDMQRLHK ELPLSLEELE DVFDALDADG NGYLTPQEFT TGFSHFFFSQ NNPSQEDAGE QVAQRHEEKV YLSRGDEDLG DMGEDEEAQF RMLMDRLGAQ KVLEDESDVK QLWLQLKKEE PHLLSNFEDF LTRIISQLQE AHEEKNELEC ALKRKIAAYD EEIQHLYEEM EQQIKSEKEQ FLLKDTERFQ ARSQELEQKL LCKEQELEQL TQKQKRLEGQ CTALHHDKHE TKAENTKLKL TNQELARELE RTSWELQDAQ QQLESLQQEA CKLHQEKEME VYRVTESLQR EKAGLLKQLD FLRERNKHLR DERDICFQKN KAAKANTAAS RASWKKRSGS VIGKYVDSRG ILRSQSEEEE EVFGIPRRSS LGLSGYPLTE EEPGTGEPGP GGPYPRPLRR IISVEEDPLP QLLDGGFEQP LSKCSEEEEV SDQGVQGQIP EAPPLKLTPT SPRGQPVGKE ALCKEESSPS APDRLFKIVF VGNSAVGKTS FLRRFCEDRF SPGMAATVGI DYRVKTLNVD NSQVALQLWD TAGQERYRCI TQQFFRKADG VIVMYDLTDK QSFLSVRRWL SSVEEAVGDR VPVLLLGNKL DNEKEREVPR GLGEQLATEN NLIFYECSAY SGHNTKESLL HLARFLKEQE DTVREDTIQV GHPAKKKSCC G
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