Protein fuzzy homolog (FUZ)

About Protein fuzzy homolog

Protein fuzzy homolog (FUZ) is a protein from Homo sapiens identified by UniProt accession Q9BT04, 418 residues long. MolForge cross-references it against 0 known binders and 149 disease associations.

Target properties

Protein name	Protein fuzzy homolog
UniProt accession	Q9BT04
Gene	FUZ
Organism	Homo sapiens
Length	418 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (149)

Diseases linked to this target (Open Targets).

caudal regression sequence · score 0.37
neural tube defect · score 0.34
neurodegenerative disease · score 0.34
Alzheimer disease · score 0.34
lysosomal storage disease · score 0.34
Parkinson disease · score 0.34
multiple sclerosis · score 0.34
short-rib thoracic dysplasia 6 with or without polydactyly · score 0.33
appendicular lean mass · score 0.17
fat body mass · score 0.14

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BT04-F1	alphafold	PREDICTED	87.46	—

Amino-acid sequence (418 residues)

MGEEGTGGTV HLLCLAASSG VPLFCRSSRG GAPARQQLPF SVIGSLNGVH MFGQNLEVQL SSARTENTTV VWKSFHDSIT LIVLSSEVGI SELRLERLLQ MVFGAMVLLV GLEELTNIRN VERLKKDLRA SYCLIDSFLG DSELIGDLTQ CVDCVIPPEG SLLQEALSGF AEAAGTTFVS LVVSGRVVAA TEGWWRLGTP EAVLLPWLVG SLPPQTARDY PVYLPHGSPT VPHRLLTLTL LPSLELCLLC GPSPPLSQLY PQLLERWWQP LLDPLRACLP LGPRALPSGF PLHTDILGLL LLHLELKRCL FTVEPLGDKE PSPEQRRRLL RNFYTLVTST HFPPEPGPPE KTEDEVYQAQ LPRACYLVLG TEEPGTGVRL VALQLGLRRL LLLLSPQSPT HGLRSLATHT LHALTPLL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards