Mitochondrial ribosome-associated GTPase 1 (MTG1)

About Mitochondrial ribosome-associated GTPase 1

Mitochondrial ribosome-associated GTPase 1 (MTG1) is a protein from Homo sapiens identified by UniProt accession Q9BT17, 334 residues long. MolForge cross-references it against 0 known binders and 124 disease associations.

Target properties

Protein name	Mitochondrial ribosome-associated GTPase 1
UniProt accession	Q9BT17
Gene	MTG1
Organism	Homo sapiens
Length	334 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (124)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.52
prostate cancer · score 0.09
Brugada syndrome · score 0.08
Romano-Ward syndrome · score 0.07
Arrhythmogenic right ventricular dysplasia · score 0.07
Familial short QT syndrome · score 0.07
hypertrophic cardiomyopathy · score 0.07
familial atrial fibrillation · score 0.07
Familial progressive cardiac conduction defect · score 0.06
ventricular fibrillation, paroxysmal familial, type 1 · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BT17-F1	alphafold	PREDICTED	87.80	—

Amino-acid sequence (334 residues)

MRLTPRALCS AAQAAWRENF PLCGRDVARW FPGHMAKGLK KMQSSLKLVD CIIEVHDARI PLSGRNPLFQ ETLGLKPHLL VLNKMDLADL TEQQKIMQHL EGEGLKNVIF TNCVKDENVK QIIPMVTELI GRSHRYHRKE NLEYCIMVIG VPNVGKSSLI NSLRRQHLRK GKATRVGGEP GITRAVMSKI QVSERPLMFL LDTPGVLAPR IESVETGLKL ALCGTVLDHL VGEETMADYL LYTLNKHQRF GYVQHYGLGS ACDNVERVLK SVAVKLGKTQ KVKVLTGTGN VNIIQPNYPA AARDFLQTFR RGLLGSVMLD LDVLRGHPPA ETLP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards