About Chitobiosyldiphosphodolichol beta-mannosyltransferase
Chitobiosyldiphosphodolichol beta-mannosyltransferase (ALG1) is a protein
from Homo sapiens identified by UniProt accession
Q9BT22, 464 residues long.
MolForge cross-references it against 0 known binders and
56 disease associations.
Target properties
| Protein name | Chitobiosyldiphosphodolichol beta-mannosyltransferase |
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| UniProt accession | Q9BT22 |
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| Gene | ALG1 |
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| Organism | Homo sapiens |
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| Length | 464 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (56)
Diseases linked to this target (Open Targets).
- ALG1-congenital disorder of glycosylation · score 0.84
- congenital disorder of glycosylation · score 0.58
- neurodegenerative disease · score 0.54
- genetic disorder · score 0.50
- congenital disorder of glycosylation type I · score 0.44
- Encephalopathy · score 0.43
- congenital nephrotic syndrome, Finnish type · score 0.29
- PMM2-congenital disorder of glycosylation · score 0.27
- neurofibrillary tangles measurement · score 0.09
- blood protein measurement · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BT22-F1 | alphafold | PREDICTED | 93.08 | — |
Amino-acid sequence (464 residues)
MAASCLVLLA LCLLLPLLLL GGWKRWRRGR AARHVVAVVL GDVGRSPRMQ YHALSLAMHG FSVTLLGFCN SKPHDELLQN NRIQIVGLTE LQSLAVGPRV FQYGVKVVLQ AMYLLWKLMW REPGAYIFLQ NPPGLPSIAV CWFVGCLCGS KLVIDWHNYG YSIMGLVHGP NHPLVLLAKW YEKFFGRLSH LNLCVTNAMR EDLADNWHIR AVTVYDKPAS FFKETPLDLQ HRLFMKLGSM HSPFRARSEP EDPVTERSAF TERDAGSGLV TRLRERPALL VSSTSWTEDE DFSILLAALE KFEQLTLDGH NLPSLVCVIT GKGPLREYYS RLIHQKHFQH IQVCTPWLEA EDYPLLLGSA DLGVCLHTSS SGLDLPMKVV DMFGCCLPVC AVNFKCLHEL VKHEENGLVF EDSEELAAQL QMLFSNFPDP AGKLNQFRKN LRESQQLRWD ESWVQTVLPL VMDT
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