Inositol polyphosphate 5-phosphatase K (INPP5K)

About Inositol polyphosphate 5-phosphatase K

Inositol polyphosphate 5-phosphatase K (INPP5K) is a protein from Homo sapiens identified by UniProt accession Q9BT40, 448 residues long. MolForge cross-references it against 0 known binders and 78 disease associations.

Target properties

Protein name	Inositol polyphosphate 5-phosphatase K
UniProt accession	Q9BT40
Gene	INPP5K
Organism	Homo sapiens
Length	448 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (78)

Diseases linked to this target (Open Targets).

muscular dystrophy, congenital, with cataracts and intellectual disability · score 0.80
genetic disorder · score 0.34
neurodegenerative disease · score 0.25
mean platelet volume · score 0.14
platelet count · score 0.08
neoplasm · score 0.07
Genital neoplasm, female · score 0.06
myeloperoxidase deficiency · score 0.05
nonimmune chronic idiopathic neutropenia of adults · score 0.05
X-linked severe congenital neutropenia · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BT40-F1	alphafold	PREDICTED	88.37	—

Amino-acid sequence (448 residues)

MSSRKLSGPK GRRLSIHVVT WNVASAAPPL DLSDLLQLNN RNLNLDIYVI GLQELNSGII SLLSDAAFND SWSSFLMDVL SPLSFIKVSH VRMQGILLLV FAKYQHLPYI QILSTKSTPT GLFGYWGNKG GVNICLKLYG YYVSIINCHL PPHISNNYQR LEHFDRILEM QNCEGRDIPN ILDHDLIIWF GDMNFRIEDF GLHFVRESIK NRCYGGLWEK DQLSIAKKHD PLLREFQEGR LLFPPTYKFD RNSNDYDTSE KKRKPAWTDR ILWRLKRQPC AGPDTPIPPA SHFSLSLRGY SSHMTYGISD HKPVSGTFDL ELKPLVSAPL IVLMPEDLWT VENDMMVSYS STSDFPSSPW DWIGLYKVGL RDVNDYVSYA WVGDSKVSCS DNLNQVYIDI SNIPTTEDEF LLCYYSNSLR SVVGISRPFQ IPPGSLREDP LGEAQPQI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards