Spexin (SPX)

About Spexin

Spexin (SPX) is a protein from Homo sapiens identified by UniProt accession Q9BT56, 116 residues long. MolForge cross-references it against 0 known binders and 108 disease associations.

Target properties

Protein name	Spexin
UniProt accession	Q9BT56
Gene	SPX
Organism	Homo sapiens
Length	116 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (108)

Diseases linked to this target (Open Targets).

mean platelet volume · score 0.18
hemoglobin measurement · score 0.17
bilirubin measurement · score 0.15
C-reactive protein measurement · score 0.15
hematocrit · score 0.14
mean corpuscular hemoglobin concentration · score 0.13
neutrophil percentage of leukocytes · score 0.12
insulin measurement · score 0.12
genetic disorder · score 0.12
serum gamma-glutamyl transferase measurement · score 0.12

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BT56-F1	alphafold	PREDICTED	66.01	—

Amino-acid sequence (116 residues)

MKGLRSLAAT TLALFLVFVF LGNSSCAPQR LLERRNWTPQ AMLYLKGAQG RRFISDQSRR KDLSDRPLPE RRSPNPQLLT IPEAATILLA SLQKSPEDEE KNFDQTRFLE DSLLNW

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards