COP9 signalosome complex subunit 4 (COPS4)

About COP9 signalosome complex subunit 4

COP9 signalosome complex subunit 4 (COPS4) is a protein from Homo sapiens identified by UniProt accession Q9BT78, 406 residues long. MolForge cross-references it against 0 known binders and 56 disease associations.

Target properties

Protein name	COP9 signalosome complex subunit 4
UniProt accession	Q9BT78
Gene	COPS4
Organism	Homo sapiens
Length	406 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (56)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.51
glioblastoma multiforme · score 0.23
lung adenocarcinoma · score 0.18
breast adenocarcinoma · score 0.18
platelet count · score 0.11
hemoglobin measurement · score 0.11
mean corpuscular volume · score 0.11
visual perception measurement · score 0.10
erythrocyte count · score 0.10
hematocrit · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BT78-F1	alphafold	PREDICTED	94.66	—

Amino-acid sequence (406 residues)

MAAAVRQDLA QLMNSSGSHK DLAGKYRQIL EKAIQLSGAE QLEALKAFVE AMVNENVSLV ISRQLLTDFC THLPNLPDST AKEIYHFTLE KIQPRVISFE EQVASIRQHL ASIYEKEEDW RNAAQVLVGI PLETGQKQYN VDYKLETYLK IARLYLEDDD PVQAEAYINR ASLLQNESTN EQLQIHYKVC YARVLDYRRK FIEAAQRYNE LSYKTIVHES ERLEALKHAL HCTILASAGQ QRSRMLATLF KDERCQQLAA YGILEKMYLD RIIRGNQLQE FAAMLMPHQK ATTADGSSIL DRAVIEHNLL SASKLYNNIT FEELGALLEI PAAKAEKIAS QMITEGRMNG FIDQIDGIVH FETREALPTW DKQIQSLCFQ VNNLLEKISQ TAPEWTAQAM EAQMAQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards