Trichoplein keratin filament-binding protein (TCHP)

About Trichoplein keratin filament-binding protein

Trichoplein keratin filament-binding protein (TCHP) is a protein from Homo sapiens identified by UniProt accession Q9BT92, 498 residues long. MolForge cross-references it against 0 known binders and 304 disease associations.

Target properties

Protein name	Trichoplein keratin filament-binding protein
UniProt accession	Q9BT92
Gene	TCHP
Organism	Homo sapiens
Length	498 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (304)

Diseases linked to this target (Open Targets).

systolic blood pressure · score 0.17
eosinophil count · score 0.15
cardiovascular disease · score 0.15
pulse pressure measurement · score 0.15
forced expiratory volume · score 0.14
leukocyte count · score 0.12
neoplasm · score 0.07
hypertension · score 0.06
blood pressure · score 0.06
hypertriglyceridemia 2 · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BT92-F1	alphafold	PREDICTED	83.61	—

Amino-acid sequence (498 residues)

MALPTLPSYW CSQQRLNQQL ARQREQEARL RQQWEQNSRY FRMSDICSSK QAEWSSKTSY QRSMHAYQRE KMKEEKRRSL EARREKLRQL MQEEQDLLAR ELEELRLSMN LQERRIREQH GKLKSAKEEQ RKLIAEQLLY EHWKKNNPKL REMELDLHQK HVVNSWEMQK EEKKQQEATA EQENKRYENE YERARREALE RMKAEEERRQ LEDKLQAEAL LQQMEELKLK EVEATKLKKE QENLLKQRWE LERLEEERKQ MEAFRQKAEL GRFLRHQYNA QLSRRTQQIQ EELEADRRIL QALLEKEDES QRLHLARREQ VMADVAWMKQ AIEEQLQLER AREAELQMLL REEAKEMWEK REAEWARERS ARDRLMSEVL TGRQQQIQEK IEQNRRAQEE SLKHREQLIR NLEEVRELAR REKEESEKLK SARKQELEAQ VAERRLQAWE ADQQEEEEEE EARRVEQLSD ALLQQEAETM AEQGYRPKPY GHPKIAWN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards