Transmembrane protein 121 (TMEM121)

About Transmembrane protein 121

Transmembrane protein 121 (TMEM121) is a protein from Homo sapiens identified by UniProt accession Q9BTD3, 319 residues long. MolForge cross-references it against 0 known binders and 48 disease associations.

Target properties

Protein name	Transmembrane protein 121
UniProt accession	Q9BTD3
Gene	TMEM121
Organism	Homo sapiens
Length	319 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (48)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.39
serum albumin measurement · score 0.33
neurodegenerative disease · score 0.31
serum IgG glycosylation measurement · score 0.30
hypothyroidism · score 0.30
immunoglobulin isotype switching measurement · score 0.30
total blood protein measurement · score 0.30
mood disorder · score 0.27
calcium measurement · score 0.27
diabetes mellitus · score 0.27

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BTD3-F1	alphafold	PREDICTED	72.83	—

Amino-acid sequence (319 residues)

MVLPPPDRRH VCLTTLVIMG SMAVMDAYLV EQNQGPRKIG VCIIVLVGDV CFLLVLRYVA VWVGAEVRTA KRGYAMILWF LYIFVLEIKL YFIFQNYKAA RRGAADPVAR KALTLLLSVC VPGLFLLLVA LDRMEYVRTF RKREDLRGRL FWVALDLLDL LDMQASLWEP PRSGLPLWAE GLTFFYCYML LLVLPCVALS EVSMQGEHIA PQKMMLYPVL SLATVNVVAV LARAANMALF RDSRVSAIFV GKNVVALATK ACTFLEYRRQ VRDFPPPALS LELQPPPPQR NSVPPPPPPL HGPPGRPHMS SPTRDPLDT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards