RNA-binding protein 42 (RBM42)

About RNA-binding protein 42

RNA-binding protein 42 (RBM42) is a protein from Homo sapiens identified by UniProt accession Q9BTD8, 480 residues long. MolForge cross-references it against 0 known binders and 14 disease associations.

Target properties

Protein name	RNA-binding protein 42
UniProt accession	Q9BTD8
Gene	RBM42
Organism	Homo sapiens
Length	480 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (14)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.54
lysosomal storage disease · score 0.31
neoplasm · score 0.01
punctate palmoplantar keratoderma type III · score 0.01
hepatitis B virus infection · score 0.01
immature platelet fraction · score 0.01
chronic obstructive pulmonary disease · score 0.01
astrocytoma · score 0.00
Thrombocytopenia · score 0.00
Au-Kline syndrome · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BTD8-F1	alphafold	PREDICTED	62.03	—

Amino-acid sequence (480 residues)

MAGAGPAPGL PGAGGPVVPG PGAGIPGKSG EERLKEMEAE MALFEQEVLG APVPGIPTAV PAVPTVPTVP TVEAMQVPAA PVIRPIIATN TYQQVQQTLE ARAAAAATVV PPMVGGPPFV GPVGFGPGDR SHLDSPEARE AMFLRRAAVA PQRAPILRPA FVPHVLQRAD SALSSAAAGP RPMALRPPHQ ALVGPPLPGP PGPPMMLPPM ARAPGPPLGS MAALRPPLEE PAAPRELGLG LGLGLKEKEE AVVAAAAGLE EASAAVAVGA GGAPAGPAVI GPSLPLALAM PLPEPEPLPL PLEVVRGLLP PLRIPELLSL RPRPRPPRPE PPPGLMALEV PEPLGEDKKK GKPEKLKRCI RTAAGSSWED PSLLEWDADD FRIFCGDLGN EVNDDILARA FSRFPSFLKA KVIRDKRTGK TKGYGFVSFK DPSDYVRAMR EMNGKYVGSR PIKLRKSMWK DRNLDVVRKK QKEKKKLGLR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards