About Dynactin subunit 5
Dynactin subunit 5 (DCTN5) is a protein
from Homo sapiens identified by UniProt accession
Q9BTE1, 182 residues long.
MolForge cross-references it against 0 known binders and
110 disease associations.
Target properties
| Protein name | Dynactin subunit 5 |
|---|
| UniProt accession | Q9BTE1 |
|---|
| Gene | DCTN5 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 182 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (110)
Diseases linked to this target (Open Targets).
- early-onset non-syndromic cataract · score 0.08
- bipolar disorder · score 0.07
- Total congenital cataract · score 0.06
- isolated ectopia lentis · score 0.06
- Cataract-microcornea syndrome · score 0.06
- hereditary hyperferritinemia with congenital cataracts · score 0.06
- Anterior polar cataract · score 0.06
- Posterior polar cataract · score 0.06
- Heterotaxia · score 0.06
- HER2 Positive Breast Carcinoma · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BTE1-F1 | alphafold | PREDICTED | 82.13 | — |
Amino-acid sequence (182 residues)
MELGELLYNK SEYIETASGN KVSRQSVLCG SQNIVLNGKT IVMNDCIIRG DLANVRVGRH CVVKSRSVIR PPFKKFSKGV AFFPLHIGDH VFIEEDCVVN AAQIGSYVHV GKNCVIGRRC VLKDCCKILD NTVLPPETVV PPFTVFSGCP GLFSGELPEC TQELMIDVTK SYYQKFLPLT QV
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