About Mini-chromosome maintenance complex-binding protein
Mini-chromosome maintenance complex-binding protein (MCMBP) is a protein
from Homo sapiens identified by UniProt accession
Q9BTE3, 642 residues long.
MolForge cross-references it against 0 known binders and
59 disease associations.
Target properties
| Protein name | Mini-chromosome maintenance complex-binding protein |
|---|
| UniProt accession | Q9BTE3 |
|---|
| Gene | MCMBP |
|---|
| Organism | Homo sapiens |
|---|
| Length | 642 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
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| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (59)
Diseases linked to this target (Open Targets).
- body height · score 0.28
- mean corpuscular volume · score 0.23
- aspartate aminotransferase measurement · score 0.20
- neurodegenerative disease · score 0.19
- mean reticulocyte volume · score 0.17
- high density lipoprotein cholesterol measurement · score 0.15
- testosterone measurement · score 0.15
- forced expiratory volume · score 0.13
- age at menarche · score 0.11
- type 2 diabetes mellitus · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BTE3-F1 | alphafold | PREDICTED | 81.32 | — |
Amino-acid sequence (642 residues)
MPCGEDWLSH PLGIVQGFFA QNGVNPDWEK KVIEYFKEKL KENNAPKWVP SLNEVPLHYL KPNSFVKFRC MIQDMFDPEF YMGVYETVNQ NTKAHVLHFG KYRDVAECGP QQELDLNSPR NTTLERQTFY CVPVPGESTW VKEAYVNANQ ARVSPSTSYT PSRHKRSYED DDDMDLQPNK QKDQHAGARQ AGSVGGLQWC GEPKRLETEA STGQQLNSLN LSSPFDLNFP LPGEKGPACL VKVYEDWDCF KVNDILELYG ILSVDPVLSI LNNDERDASA LLDPMECTDT AEEQRVHSPP ASLVPRIHVI LAQKLQHINP LLPACLNKEE SKTCKFVSSF MSELSPVRAE LLGFLTHALL GDSLAAEYLI LHLISTVYTR RDVLPLGKFT VNLSGCPRNS TFTEHLYRII QHLVPASFRL QMTIENMNHL KFIPHKDYTA NRLVSGLLQL PSNTSLVIDE TLLEQGQLDT PGVHNVTALS NLITWQKVDY DFSYHQMEFP CNINVFITSE GRSLLPADCQ IHLQPQLIPP NMEEYMNSLL SAVLPSVLNK FRIYLTLLRF LEYSISDEIT KAVEDDFVEM RKNDPQSITA DDLHQLLVVA RCLSLSAGQT TLSRERWLRA KQLESLRRTR LQQQKCVNGN EL
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