About U6 snRNA (guanine-N(2))-methyltransferase THUMPD2
U6 snRNA (guanine-N(2))-methyltransferase THUMPD2 (THUMPD2) is a protein
from Homo sapiens identified by UniProt accession
Q9BTF0, 503 residues long.
MolForge cross-references it against 0 known binders and
43 disease associations.
Target properties
| Protein name | U6 snRNA (guanine-N(2))-methyltransferase THUMPD2 |
|---|
| UniProt accession | Q9BTF0 |
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| Gene | THUMPD2 |
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| Organism | Homo sapiens |
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| Length | 503 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (43)
Diseases linked to this target (Open Targets).
- protein measurement · score 0.19
- PHF-tau measurement · score 0.18
- lean body mass · score 0.09
- body mass index · score 0.08
- fat body mass · score 0.08
- body weight · score 0.08
- grip strength measurement · score 0.07
- body fat percentage · score 0.07
- sleep duration · score 0.07
- systemic lupus erythematosus · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BTF0-F1 | alphafold | PREDICTED | 74.97 | — |
Amino-acid sequence (503 residues)
MSEARGEPGS GPEAGARFFC TAGRGLEPFV MREVRARLAA TQVEYISGKV FFTTCSDLNM LKKLKSAERL FLLIKKQFPL IISSVSKGKI FNEMQRLINE DPGSWLNAIS IWKNLLELDA KKEKLSQRDD NQLKRKVGEN EIIAKKLKIE QMQKIEENRD CQLEKQIKEE TLEQRDFTTK SEKFQEEEFQ NDIEKAIDTH NQNDLTFRVS CRCSGTIGKA FTAQEVGKVI GIAIMKHFGW KADLRNPQLE IFIHLNDIYS VVGIPVFRVS LASRAYIKTA GLRSTIAWAM ASLADIKAGA FVLDPMCGLG TILLEAAKEW PDVYYVGADV SDSQLLGTWD NLKAAGLEDK IELLKISVIE LPLPSESVDI IISDIPFGKK FKLGKDIKSI LQEMERVLHV GGTIVLLLSE DHHRRLTDCK ESNIPFNSKD SHTDEPGIKK CLNPEEKTGA FKTASTSFEA SNHKFLDRMS PFGSLVPVEC YKVSLGKTDA FICKYKKSHS SGL
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