About Immediate early response gene 2 protein
Immediate early response gene 2 protein (IER2) is a protein
from Homo sapiens identified by UniProt accession
Q9BTL4, 223 residues long.
MolForge cross-references it against 0 known binders and
61 disease associations.
Target properties
| Protein name | Immediate early response gene 2 protein |
|---|
| UniProt accession | Q9BTL4 |
|---|
| Gene | IER2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 223 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (61)
Diseases linked to this target (Open Targets).
- body height · score 0.37
- sex hormone-binding globulin measurement · score 0.25
- appendicular lean mass · score 0.22
- venous thromboembolism · score 0.18
- age at first birth measurement · score 0.17
- brain volume measurement · score 0.15
- mathematical ability · score 0.15
- self reported educational attainment · score 0.14
- neurodegenerative disease · score 0.13
- melanoma · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BTL4-F1 | alphafold | PREDICTED | 63.42 | — |
Amino-acid sequence (223 residues)
MEVQKEAQRI MTLSVWKMYH SRMQRGGLRL HRSLQLSLVM RSARELYLSA KVEALEPEVS LPAALPSDPR LHPPREAEST AETATPDGEH PFPEPMDTQE APTAEETSAC CAPRPAKVSR KRRSSSLSDG GDAGLVPSKK ARLEEKEEEE GASSEVADRL QPPPAQAEGA FPNLARVLQR RFSGLLNCSP AAPPTAPPAC EAKPACRPAD SMLNVLVRAV VAF
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