Histone H2A.J (H2AJ)

About Histone H2A.J

Histone H2A.J (H2AJ) is a protein from Homo sapiens identified by UniProt accession Q9BTM1, 129 residues long. MolForge cross-references it against 0 known binders and 24 disease associations.

Target properties

Protein name	Histone H2A.J
UniProt accession	Q9BTM1
Gene	H2AJ
Organism	Homo sapiens
Length	129 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (24)

Diseases linked to this target (Open Targets).

cancer · score 0.37
breast carcinoma · score 0.37
melanoma · score 0.37
body height · score 0.22
prostate carcinoma · score 0.19
lean body mass · score 0.09
fat body mass · score 0.08
glioblastoma multiforme · score 0.07
BMI-adjusted hip circumference · score 0.07
base metabolic rate measurement · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BTM1-F1	alphafold	PREDICTED	91.17	—

Amino-acid sequence (129 residues)

MSGRGKQGGK VRAKAKSRSS RAGLQFPVGR VHRLLRKGNY AERVGAGAPV YLAAVLEYLT AEILELAGNA ARDNKKTRII PRHLQLAIRN DEELNKLLGK VTIAQGGVLP NIQAVLLPKK TESQKTKSK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards