Mediator of RNA polymerase II transcription subunit 10 (MED10)

About Mediator of RNA polymerase II transcription subunit 10

Mediator of RNA polymerase II transcription subunit 10 (MED10) is a protein from Homo sapiens identified by UniProt accession Q9BTT4, 135 residues long. MolForge cross-references it against 0 known binders and 69 disease associations.

Target properties

Protein name	Mediator of RNA polymerase II transcription subunit 10
UniProt accession	Q9BTT4
Gene	MED10
Organism	Homo sapiens
Length	135 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (69)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.50
von Willebrand factor measurement · score 0.16
bladder transitional cell carcinoma · score 0.07
Blackfan-Diamond anemia · score 0.05
hemoglobin D disease · score 0.05
hereditary persistence of fetal hemoglobin-sickle cell disease syndrome · score 0.05
ulcerative colitis · score 0.05
hereditary persistence of fetal hemoglobin-beta-thalassemia syndrome · score 0.05
hemoglobin E disease · score 0.04
dominant beta-thalassemia · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BTT4-F1	alphafold	PREDICTED	92.77	—

Amino-acid sequence (135 residues)

MAEKFDHLEE HLEKFVENIR QLGIIVSDFQ PSSQAGLNQK LNFIVTGLQD IDKCRQQLHD ITVPLEVFEY IDQGRNPQLY TKECLERALA KNEQVKGKID TMKKFKSLLI QELSKVFPED MAKYRSIRGE DHPPS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards