About Leucine-rich repeat-containing protein 1
Leucine-rich repeat-containing protein 1 (LRRC1) is a protein
from Homo sapiens identified by UniProt accession
Q9BTT6, 524 residues long.
MolForge cross-references it against 0 known binders and
39 disease associations.
Target properties
| Protein name | Leucine-rich repeat-containing protein 1 |
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| UniProt accession | Q9BTT6 |
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| Gene | LRRC1 |
|---|
| Organism | Homo sapiens |
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| Length | 524 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (39)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.38
- heel bone mineral density · score 0.24
- bone quantitative ultrasound measurement · score 0.24
- urate measurement · score 0.24
- type 2 diabetes mellitus · score 0.19
- waist-hip ratio · score 0.19
- pulse pressure measurement · score 0.18
- non-small cell lung carcinoma · score 0.07
- hepatocellular carcinoma · score 0.04
- appendicular lean mass · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BTT6-F1 | alphafold | PREDICTED | 85.73 | — |
Amino-acid sequence (524 residues)
MFHCIPLWRC NRHVESIDKR HCSLVYVPEE IYRYARSLEE LLLDANQLRE LPEQFFQLVK LRKLGLSDNE IQRLPPEIAN FMQLVELDVS RNEIPEIPES ISFCKALQVA DFSGNPLTRL PESFPELQNL TCLSVNDISL QSLPENIGNL YNLASLELRE NLLTYLPDSL TQLRRLEELD LGNNEIYNLP ESIGALLHLK DLWLDGNQLS ELPQEIGNLK NLLCLDVSEN RLERLPEEIS GLTSLTDLVI SQNLLETIPD GIGKLKKLSI LKVDQNRLTQ LPEAVGECES LTELVLTENQ LLTLPKSIGK LKKLSNLNAD RNKLVSLPKE IGGCCSLTVF CVRDNRLTRI PAEVSQATEL HVLDVAGNRL LHLPLSLTAL KLKALWLSDN QSQPLLTFQT DTDYTTGEKI LTCVLLPQLP SEPTCQENLP RCGALENLVN DVSDEAWNER AVNRVSAIRF VEDEKDEEDN ETRTLLRRAT PHPGELKHMK KTVENLRNDM NAAKGLDSNK NEVNHAIDRV TTSV
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