About Phosphatidylinositol 4-kinase type 2-alpha
Phosphatidylinositol 4-kinase type 2-alpha (PI4K2A) is a protein
from Homo sapiens identified by UniProt accession
Q9BTU6, 479 residues long.
MolForge cross-references it against 0 known binders and
80 disease associations.
Target properties
| Protein name | Phosphatidylinositol 4-kinase type 2-alpha |
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| UniProt accession | Q9BTU6 |
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| Gene | PI4K2A |
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| Organism | Homo sapiens |
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| Length | 479 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (80)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.43
- cutaneous melanoma · score 0.18
- lung cancer · score 0.06
- Young adult-onset Parkinsonism · score 0.04
- cancer · score 0.04
- Autosomal dominant spastic paraplegia type 12 · score 0.04
- Spinocerebellar ataxia type 42 · score 0.04
- neurodegeneration with ataxia, dystonia, and gaze palsy, childhood-onset · score 0.04
- metabolite measurement · score 0.04
- Spinocerebellar ataxia type 40 · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BTU6-F1 | alphafold | PREDICTED | 79.32 | — |
Amino-acid sequence (479 residues)
MDETSPLVSP ERAQPPDYTF PSGSGAHFPQ VPGGAVRVAA AAGSGPSPPG SPGHDRERQP LLDRARGAAA QGQTQTVAAQ AQALAAQAAA AAHAAQAHRE RNEFPEDPEF EAVVRQAELA IERCIFPERI YQGSSGSYFV KDPQGRIIAV FKPKNEEPYG HLNPKWTKWL QKLCCPCCFG RDCLVLNQGY LSEAGASLVD QKLELNIVPR TKVVYLASET FNYSAIDRVK SRGKRLALEK VPKVGQRFNR IGLPPKVGSF QLFVEGYKDA DYWLRRFEAE PLPENTNRQL LLQFERLVVL DYIIRNTDRG NDNWLIKYDC PMDSSSSRDT DWVVVKEPVI KVAAIDNGLA FPLKHPDSWR AYPFYWAWLP QAKVPFSQEI KDLILPKISD PNFVKDLEED LYELFKKDPG FDRGQFHKQI AVMRGQILNL TQALKDNKSP LHLVQMPPVI VETARSHQRS SSESYTQSFQ SRKPFFSWW
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