About Transmembrane protein 43
Transmembrane protein 43 (TMEM43) is a protein
from Homo sapiens identified by UniProt accession
Q9BTV4, 400 residues long.
MolForge cross-references it against 0 known binders and
135 disease associations.
Target properties
| Protein name | Transmembrane protein 43 |
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| UniProt accession | Q9BTV4 |
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| Gene | TMEM43 |
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| Organism | Homo sapiens |
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| Length | 400 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (135)
Diseases linked to this target (Open Targets).
- arrhythmogenic right ventricular dysplasia 5 · score 0.71
- Emery-Dreifuss muscular dystrophy 7, autosomal dominant · score 0.70
- Arrhythmogenic right ventricular dysplasia · score 0.61
- arrhythmogenic right ventricular cardiomyopathy · score 0.52
- cardiomyopathy · score 0.44
- Abnormality of the cardiovascular system · score 0.42
- dilated cardiomyopathy · score 0.37
- hypertrophic cardiomyopathy · score 0.37
- familial isolated arrhythmogenic ventricular dysplasia, left dominant form · score 0.37
- familial isolated arrhythmogenic ventricular dysplasia, biventricular form · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BTV4-F1 | alphafold | PREDICTED | 89.95 | — |
Amino-acid sequence (400 residues)
MAANYSSTST RREHVKVKTS SQPGFLERLS ETSGGMFVGL MAFLLSFYLI FTNEGRALKT ATSLAEGLSL VVSPDSIHSV APENEGRLVH IIGALRTSKL LSDPNYGVHL PAVKLRRHVE MYQWVETEES REYTEDGQVK KETRYSYNTE WRSEIINSKN FDREIGHKNP SAMAVESFMA TAPFVQIGRF FLSSGLIDKV DNFKSLSLSK LEDPHVDIIR RGDFFYHSEN PKYPEVGDLR VSFSYAGLSG DDPDLGPAHV VTVIARQRGD QLVPFSTKSG DTLLLLHHGD FSAEEVFHRE LRSNSMKTWG LRAAGWMAMF MGLNLMTRIL YTLVDWFPVF RDLVNIGLKA FAFCVATSLT LLTVAAGWLF YRPLWALLIA GLALVPILVA RTRVPAKKLE
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