CDK5 and ABL1 enzyme substrate 2 (CABLES2)

About CDK5 and ABL1 enzyme substrate 2

CDK5 and ABL1 enzyme substrate 2 (CABLES2) is a protein from Homo sapiens identified by UniProt accession Q9BTV7, 478 residues long. MolForge cross-references it against 0 known binders and 41 disease associations.

Target properties

Protein name	CDK5 and ABL1 enzyme substrate 2
UniProt accession	Q9BTV7
Gene	CABLES2
Organism	Homo sapiens
Length	478 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (41)

Diseases linked to this target (Open Targets).

Immature Reticulocyte Fraction Measurement · score 0.37
colorectal cancer · score 0.36
serum albumin measurement · score 0.29
total blood protein measurement · score 0.23
platelet crit · score 0.16
esophageal cancer · score 0.15
body height · score 0.14
intestinal cancer · score 0.14
colonic neoplasm · score 0.10
mean corpuscular volume · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BTV7-F1	alphafold	PREDICTED	59.78	—

Amino-acid sequence (478 residues)

MAAAAAGGAP GPAPGPAGPP PPAAPTSAAR APPQALRRRG DSRRRQAALF FLNNISLDGR PPSLGPGGEK PPPPPAEARE PPAPPPPEPP TGLPARTPAP QGLLSPTQVP TGLGLDGQRQ RKRVTSQRCS LEFLEDAVGC APAQRTKHTS GSPRHKGLKK THFIKNMRQY DTRNSRIVLI CAKRSLCAAF SVLPYGEGLR ISDLRVDSQK QRHPSGGVSV SSEMVFELEG VELGADGKVV SYAKFLYPTN ALVTHKSDSH GLLPTPRPSV PRTLPGSRHK PAPTKSAPAS TELGSDVGDT LEYNPNLLDD PQWPCGKHKR VLIFASYMTT VIEYVKPSDL KKDMNETFRE KFPHVKLTLS KIRSLKREMR SLSEECSLEP VTVAMAYVYF EKLVLQGKLS KQNRKLCAGA CVLLAAKISS DLRKSGVTQL IDKLEERFRF NRRDLIGFEF TVLVALELAL YLPENQVLPH YRRLTQQF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards