Plasma alpha-L-fucosidase (FUCA2)

About Plasma alpha-L-fucosidase

Plasma alpha-L-fucosidase (FUCA2) is a protein from Homo sapiens identified by UniProt accession Q9BTY2, 467 residues long. MolForge cross-references it against 0 known binders and 44 disease associations.

Target properties

Protein name	Plasma alpha-L-fucosidase
UniProt accession	Q9BTY2
Gene	FUCA2
Organism	Homo sapiens
Length	467 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (44)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.32
pulse pressure measurement · score 0.26
PHF-tau measurement · score 0.13
Myopia · score 0.11
pathological myopia · score 0.11
neoplasm · score 0.08
cancer · score 0.08
hepatocellular carcinoma · score 0.08
chronotype measurement · score 0.03
adolescent idiopathic scoliosis · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BTY2-F1	alphafold	PREDICTED	93.63	—

Amino-acid sequence (467 residues)

MRPQELPRLA FPLLLLLLLL LPPPPCPAHS ATRFDPTWES LDARQLPAWF DQAKFGIFIH WGVFSVPSFG SEWFWWYWQK EKIPKYVEFM KDNYPPSFKY EDFGPLFTAK FFNANQWADI FQASGAKYIV LTSKHHEGFT LWGSEYSWNW NAIDEGPKRD IVKELEVAIR NRTDLRFGLY YSLFEWFHPL FLEDESSSFH KRQFPVSKTL PELYELVNNY QPEVLWSDGD GGAPDQYWNS TGFLAWLYNE SPVRGTVVTN DRWGAGSICK HGGFYTCSDR YNPGHLLPHK WENCMTIDKL SWGYRREAGI SDYLTIEELV KQLVETVSCG GNLLMNIGPT LDGTISVVFE ERLRQMGSWL KVNGEAIYET HTWRSQNDTV TPDVWYTSKP KEKLVYAIFL KWPTSGQLFL GHPKAILGAT EVKLLGHGQP LNWISLEQNG IMVELPQLTI HQMPCKWGWA LALTNVI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards