Ciliogenesis and planar polarity effector 2 (CPLANE2)

About Ciliogenesis and planar polarity effector 2

Ciliogenesis and planar polarity effector 2 (CPLANE2) is a protein from Homo sapiens identified by UniProt accession Q9BU20, 258 residues long. MolForge cross-references it against 0 known binders and 140 disease associations.

Target properties

Protein name	Ciliogenesis and planar polarity effector 2
UniProt accession	Q9BU20
Gene	CPLANE2
Organism	Homo sapiens
Length	258 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (140)

Diseases linked to this target (Open Targets).

cystatin C measurement · score 0.25
glomerular filtration rate · score 0.22
mean corpuscular hemoglobin concentration · score 0.21
creatinine measurement · score 0.17
eosinophil count · score 0.15
serum gamma-glutamyl transferase measurement · score 0.12
serum alanine aminotransferase measurement · score 0.12
sex hormone-binding globulin measurement · score 0.11
aspartate aminotransferase measurement · score 0.11
calcium measurement · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BU20-F1	alphafold	PREDICTED	90.07	—

Amino-acid sequence (258 residues)

MARPPVPGSV VVPNWHESAE GKEYLACILR KNRRRVFGLL ERPVLLPPVS IDTASYKIFV SGKSGVGKTA LVAKLAGLEV PVVHHETTGI QTTVVFWPAK LQASSRVVMF RFEFWDCGES ALKKFDHMLL ACMENTDAFL FLFSFTDRAS FEDLPGQLAR IAGEAPGVVR MVIGSKFDQY MHTDVPERDL TAFRQAWELP LLRVKSVPGR RLADGRTLDG RAGLADVAHI LNGLAEQLWH QDQVAAGLLP NPPESAPE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards