About Centromere protein O
Centromere protein O (CENPO) is a protein
from Homo sapiens identified by UniProt accession
Q9BU64, 300 residues long.
MolForge cross-references it against 0 known binders and
81 disease associations.
Target properties
| Protein name | Centromere protein O |
|---|
| UniProt accession | Q9BU64 |
|---|
| Gene | CENPO |
|---|
| Organism | Homo sapiens |
|---|
| Length | 300 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (81)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.37
- body height · score 0.35
- parkinsonian disorder · score 0.34
- Parkinson disease · score 0.34
- obesity due to melanocortin 4 receptor deficiency · score 0.24
- grip strength measurement · score 0.23
- appendicular lean mass · score 0.22
- intelligence · score 0.22
- body fat percentage · score 0.22
- multiple sclerosis · score 0.21
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BU64-F1 | alphafold | PREDICTED | 85.20 | — |
Amino-acid sequence (300 residues)
MEQANPLRPD GESKGGVLAH LERLETQVSR SRKQSEELQS VQAQEGALGT KIHKLRRLRD ELRAVVRHRR ASVKACIANV EPNQTVEINE QEALEEKLEN VKAILQAYHF TGLSGKLTSR GVCVCISTAF EGNLLDSYFV DLVIQKPLRI HHHSVPVFIP LEEIAAKYLQ TNIQHFLFSL CEYLNAYSGR KYQADRLQSD FAALLTGPLQ RNPLCNLLSF TYKLDPGGQS FPFCARLLYK DLTATLPTDV TVTCQGVEVL STSWEEQRAS HETLFCTKPL HQVFASFTRK GEKLDMSLVS
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