tRNA (adenine(37)-N6)-methyltransferase (TRMO)

About tRNA (adenine(37)-N6)-methyltransferase

tRNA (adenine(37)-N6)-methyltransferase (TRMO) is a protein from Homo sapiens identified by UniProt accession Q9BU70, 441 residues long. MolForge cross-references it against 0 known binders and 40 disease associations.

Target properties

Protein name	tRNA (adenine(37)-N6)-methyltransferase
UniProt accession	Q9BU70
Gene	TRMO
Organism	Homo sapiens
Length	441 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (40)

Diseases linked to this target (Open Targets).

mean platelet volume · score 0.37
platelet count · score 0.36
thyroid carcinoma · score 0.32
blood protein measurement · score 0.29
HbA1c measurement · score 0.27
thyroid stimulating hormone measurement · score 0.24
platelet component distribution width · score 0.24
platelet crit · score 0.23
thyroid cancer · score 0.22
Red cell distribution width · score 0.19

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BU70-F1	alphafold	PREDICTED	67.47	—

Amino-acid sequence (441 residues)

MRGLEESGPR PTATPCGCVK PALETGNLLT EPVGYLESCF SAKNGTPRQP SICSYSRACL RIRKRIFNNP EHSLMGLEQF SHVWILFVFH KNGHLSCKAK VQPPRLNGAK TGVFSTRSPH RPNAIGLTLA KLEKVEGGAI YLSGIDMIHG TPVLDIKPYI AEYDSPQNVM EPLADFNLQN NQHTPNTVSQ SDSKTDSCDQ RQLSGCDEPQ PHHSTKRKPK CPEDRTSEEN YLTHSDTARI QQAFPMHREI AVDFGLESRR DQSSSVAEEQ IGPYCPEKSF SEKGTDKKLE RVEGAAVLQG SRAETQPMAP HCPAGRADGA PRSVVPAWVT EAPVATLEVR FTPHAEMDLG QLSSQDVGQA SFKYFQSAEE AKRAIEAVLS ADPRSVYRRK LCQDRLFYFT VDIAHVTCWF GDGFAEVLRI KPASEPVHMT GPVGSLVSLG S

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards