Deoxyhypusine hydroxylase (DOHH)

About Deoxyhypusine hydroxylase

Deoxyhypusine hydroxylase (DOHH) is a protein from Homo sapiens identified by UniProt accession Q9BU89, 302 residues long. MolForge cross-references it against 0 known binders and 49 disease associations.

Target properties

Protein name	Deoxyhypusine hydroxylase
UniProt accession	Q9BU89
Gene	DOHH
Organism	Homo sapiens
Length	302 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (4)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (49)

Diseases linked to this target (Open Targets).

neurodevelopmental disorder with microcephaly, cerebral atrophy, and visual impairment · score 0.67
complex neurodevelopmental disorder · score 0.37
neurodegenerative disease · score 0.36
Neurodevelopmental disorder · score 0.19
neuronal ceroid lipofuscinosis 1 · score 0.04
familial isolated congenital asplenia · score 0.04
body height · score 0.04
skin pigmentation measurement · score 0.04
Red cell distribution width · score 0.04
high density lipoprotein cholesterol measurement · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BU89-F1	alphafold	PREDICTED	96.06	—

Amino-acid sequence (302 residues)

MVTEQEVDAI GQTLVDPKQP LQARFRALFT LRGLGGPGAI AWISQAFDDD SALLKHELAY CLGQMQDARA IPMLVDVLQD TRQEPMVRHE AGEALGAIGD PEVLEILKQY SSDPVIEVAE TCQLAVRRLE WLQQHGGEPA AGPYLSVDPA PPAEERDVGR LREALLDESR PLFERYRAMF ALRNAGGEEA ALALAEGLHC GSALFRHEVG YVLGQLQHEA AVPQLAAALA RCTENPMVRH ECAEALGAIA RPACLAALQA HADDPERVVR ESCEVALDMY EHETGRAFQY ADGLEQLRGA PS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards