About tRNA-specific adenosine deaminase 1
tRNA-specific adenosine deaminase 1 (ADAT1) is a protein
from Homo sapiens identified by UniProt accession
Q9BUB4, 502 residues long.
MolForge cross-references it against 0 known binders and
22 disease associations.
Target properties
| Protein name | tRNA-specific adenosine deaminase 1 |
|---|
| UniProt accession | Q9BUB4 |
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| Gene | ADAT1 |
|---|
| Organism | Homo sapiens |
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| Length | 502 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (22)
Diseases linked to this target (Open Targets).
- smoking behaviour measurement · score 0.26
- self reported educational attainment · score 0.24
- smoking status measurement · score 0.24
- age at first sexual intercourse measurement · score 0.18
- attention deficit hyperactivity disorder · score 0.18
- substance abuse · score 0.18
- antisocial behaviour measurement · score 0.18
- smoking behavior · score 0.17
- smoking initiation · score 0.17
- PHF-tau measurement · score 0.16
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BUB4-F1 | alphafold | PREDICTED | 81.73 | — |
Amino-acid sequence (502 residues)
MWTADEIAQL CYEHYGIRLP KKGKPEPNHE WTLLAAVVKI QSPADKACDT PDKPVQVTKE VVSMGTGTKC IGQSKMRKNG DILNDSHAEV IARRSFQRYL LHQLQLAATL KEDSIFVPGT QKGVWKLRRD LIFVFFSSHT PCGDASIIPM LEFEDQPCCP VFRNWAHNSS VEASSNLEAP GNERKCEDPD SPVTKKMRLE PGTAAREVTN GAAHHQSFGK QKSGPISPGI HSCDLTVEGL ATVTRIAPGS AKVIDVYRTG AKCVPGEAGD SGKPGAAFHQ VGLLRVKPGR GDRTRSMSCS DKMARWNVLG CQGALLMHLL EEPIYLSAVV IGKCPYSQEA MQRALIGRCQ NVSALPKGFG VQELKILQSD LLFEQSRSAV QAKRADSPGR LVPCGAAISW SAVPEQPLDV TANGFPQGTT KKTIGSLQAR SQISKVELFR SFQKLLSRIA RDKWPHSLRV QKLDTYQEYK EAASSYQEAW STLRKQVFGS WIRNPPDYHQ FK
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