MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)

About MAP kinase-interacting serine/threonine-protein kinase 1

MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) is a protein from Homo sapiens identified by UniProt accession Q9BUB5, 465 residues long. MolForge cross-references it against 0 known binders and 108 disease associations.

Target properties

Protein name	MAP kinase-interacting serine/threonine-protein kinase 1
UniProt accession	Q9BUB5
Gene	MKNK1
Organism	Homo sapiens
Length	465 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (9)

DrugCentral-linked approved drugs that act on this protein.

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BUB5-F1	alphafold	PREDICTED	69.88	—

Amino-acid sequence (465 residues)

MVSSQKLEKP IEMGSSEPLP IADGDRRRKK KRRGRATDSL PGKFEDMYKL TSELLGEGAY AKVQGAVSLQ NGKEYAVKII EKQAGHSRSR VFREVETLYQ CQGNKNILEL IEFFEDDTRF YLVFEKLQGG SILAHIQKQK HFNEREASRV VRDVAAALDF LHTKDKVSLC HLGWSAMAPS GLTAAPTSLG SSDPPTSASQ VAGTTGIAHR DLKPENILCE SPEKVSPVKI CDFDLGSGMK LNNSCTPITT PELTTPCGSA EYMAPEVVEV FTDQATFYDK RCDLWSLGVV LYIMLSGYPP FVGHCGADCG WDRGEVCRVC QNKLFESIQE GKYEFPDKDW AHISSEAKDL ISKLLVRDAK QRLSAAQVLQ HPWVQGQAPE KGLPTPQVLQ RNSSTMDLTL FAAEAIALNR QLSQHEENEL AEEPEALADG LCSMKLSPPC KSRLARRRAL AQAGRGEDRS PPTAL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards