About Spondin-2
Spondin-2 (SPON2) is a protein
from Homo sapiens identified by UniProt accession
Q9BUD6, 331 residues long.
MolForge cross-references it against 0 known binders and
174 disease associations.
Target properties
| Protein name | Spondin-2 |
|---|
| UniProt accession | Q9BUD6 |
|---|
| Gene | SPON2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 331 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (174)
Diseases linked to this target (Open Targets).
- Immature Reticulocyte Fraction Measurement · score 0.23
- blood protein measurement · score 0.20
- thyroid gland adenocarcinoma · score 0.18
- gastric adenocarcinoma · score 0.18
- urate measurement · score 0.14
- glioblastoma multiforme · score 0.13
- neoplasm · score 0.11
- reticulocyte measurement · score 0.10
- heel bone mineral density · score 0.10
- reticulocyte count · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BUD6-F1 | alphafold | PREDICTED | 87.62 | — |
Amino-acid sequence (331 residues)
MENPSPAAAL GKALCALLLA TLGAAGQPLG GESICSARAL AKYSITFTGK WSQTAFPKQY PLFRPPAQWS SLLGAAHSSD YSMWRKNQYV SNGLRDFAER GEAWALMKEI EAAGEALQSV HAVFSAPAVP SGTGQTSAEL EVQRRHSLVS FVVRIVPSPD WFVGVDSLDL CDGDRWREQA ALDLYPYDAG TDSGFTFSSP NFATIPQDTV TEITSSSPSH PANSFYYPRL KALPPIARVT LVRLRQSPRA FIPPAPVLPS RDNEIVDSAS VPETPLDCEV SLWSSWGLCG GHCGRLGTKS RTRYVRVQPA NNGSPCPELE EEAECVPDNC V
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