About Iron-sulfur cluster assembly 1 homolog, mitochondrial
Iron-sulfur cluster assembly 1 homolog, mitochondrial (ISCA1) is a protein
from Homo sapiens identified by UniProt accession
Q9BUE6, 129 residues long.
MolForge cross-references it against 0 known binders and
66 disease associations.
Target properties
| Protein name | Iron-sulfur cluster assembly 1 homolog, mitochondrial |
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| UniProt accession | Q9BUE6 |
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| Gene | ISCA1 |
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| Organism | Homo sapiens |
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| Length | 129 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (66)
Diseases linked to this target (Open Targets).
- Fatal multiple mitochondrial dysfunction syndrome · score 0.69
- neurodegenerative disease · score 0.51
- Red cell distribution width · score 0.35
- fatal multiple mitochondrial dysfunctions syndrome · score 0.34
- Fatal multiple mitochondrial dysfunction syndrome type 2 · score 0.33
- reticulocyte count · score 0.21
- body mass index · score 0.21
- FEV/FVC ratio · score 0.19
- cortical thickness · score 0.17
- cortical surface area measurement · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BUE6-F1 | alphafold | PREDICTED | 89.94 | — |
Amino-acid sequence (129 residues)
MSASLVRATV RAVSKRKLQP TRAALTLTPS AVNKIKQLLK DKPEHVGVKV GVRTRGCNGL SYTLEYTKTK GDSDEEVIQD GVRVFIEKKA QLTLLGTEMD YVEDKLSSEF VFNNPNIKGT CGCGESFNI
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