Tubulin beta-6 chain (TUBB6)

About Tubulin beta-6 chain

Tubulin beta-6 chain (TUBB6) is a protein from Homo sapiens identified by UniProt accession Q9BUF5, 446 residues long. MolForge cross-references it against 0 known binders and 519 disease associations.

Target properties

Protein name	Tubulin beta-6 chain
UniProt accession	Q9BUF5
Gene	TUBB6
Organism	Homo sapiens
Length	446 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (519)

Diseases linked to this target (Open Targets).

head and neck squamous cell carcinoma · score 0.61
non-small cell lung carcinoma · score 0.61
breast cancer · score 0.61
breast carcinoma · score 0.60
neoplasm · score 0.60
breast neoplasm · score 0.60
gout · score 0.59
acute lymphoblastic leukemia · score 0.59
Hodgkins lymphoma · score 0.59
prostate cancer · score 0.59

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BUF5-F1	alphafold	PREDICTED	92.64	—

Amino-acid sequence (446 residues)

MREIVHIQAG QCGNQIGTKF WEVISDEHGI DPAGGYVGDS ALQLERINVY YNESSSQKYV PRAALVDLEP GTMDSVRSGP FGQLFRPDNF IFGQTGAGNN WAKGHYTEGA ELVDAVLDVV RKECEHCDCL QGFQLTHSLG GGTGSGMGTL LISKIREEFP DRIMNTFSVM PSPKVSDTVV EPYNATLSVH QLVENTDETY CIDNEALYDI CFRTLKLTTP TYGDLNHLVS ATMSGVTTSL RFPGQLNADL RKLAVNMVPF PRLHFFMPGF APLTSRGSQQ YRALTVPELT QQMFDARNMM AACDPRHGRY LTVATVFRGP MSMKEVDEQM LAIQSKNSSY FVEWIPNNVK VAVCDIPPRG LKMASTFIGN STAIQELFKR ISEQFSAMFR RKAFLHWFTG EGMDEMEFTE AESNMNDLVS EYQQYQDATA NDGEEAFEDE EEEIDG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards