About Brain-enriched guanylate kinase-associated protein
Brain-enriched guanylate kinase-associated protein (BEGAIN) is a protein
from Homo sapiens identified by UniProt accession
Q9BUH8, 593 residues long.
MolForge cross-references it against 0 known binders and
50 disease associations.
Target properties
| Protein name | Brain-enriched guanylate kinase-associated protein |
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| UniProt accession | Q9BUH8 |
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| Gene | BEGAIN |
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| Organism | Homo sapiens |
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| Length | 593 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (50)
Diseases linked to this target (Open Targets).
- chronotype measurement · score 0.44
- neurodegenerative disease · score 0.36
- age at menarche · score 0.31
- neuroinflammatory disorder · score 0.30
- gait measurement · score 0.21
- metabolite measurement · score 0.16
- insomnia measurement · score 0.15
- body mass index · score 0.10
- body weight · score 0.10
- body height · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BUH8-F1 | alphafold | PREDICTED | 55.90 | — |
Amino-acid sequence (593 residues)
MEKLSALQEQ KGELRKRLSY TTHKLEKLET EFDSTRHYLE IELRRAQEEL EKVTEKLRRI QSNYMALQRI NQELEDKLYR MGQHYEEEKR ALSHEIVALN SHLLEAKVTI DKLSEDNELY RKDCNLAAQL LQCSQTYGRV HKVSELPSDF QERVSLHMEK HGCSLPSPLC HPAYADSVPT CVIAKVLEKP DPASLSSRLS DASARDLAFC DGVEKPGPRP PYKGDIYCSD TALYCPEERR RDRRPSVDAP VTDVGFLRAQ NSTDSAAEEE EEAEAAAFPA GFQHEAFPSY AGSLPTSSSY SSFSATSEEK EHAQASTLTA SQQAIYLNSR DELFDRKPPA TTYEGSPRFA KATAAVAAPL EAEVAPGFGR TMSPYPAETF RFPASPGPQQ ALMPPNLWSL RAKPGTARLP GEDMRGQWRP LSVEDIGAYS YPVSAAGRAS PCSFSERYYG GAGGSPGKKA DGRASPLYAS YKADSFSEGD DLSQGHLAEP CFLRAGGDLS LSPGRSADPL PGYAPSEGGD GDRLGVQLCG TASSPEPEQG SRDSLEPSSM EASPEMHPAA RLSPQQAFPR TGGSGLSRKD SLTKAQLYGT LLN
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