About DNA-directed RNA polymerase III subunit RPC3
DNA-directed RNA polymerase III subunit RPC3 (POLR3C) is a protein
from Homo sapiens identified by UniProt accession
Q9BUI4, 534 residues long.
MolForge cross-references it against 0 known binders and
22 disease associations.
Target properties
| Protein name | DNA-directed RNA polymerase III subunit RPC3 |
|---|
| UniProt accession | Q9BUI4 |
|---|
| Gene | POLR3C |
|---|
| Organism | Homo sapiens |
|---|
| Length | 534 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (22)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.37
- endometrial cancer · score 0.18
- urate measurement · score 0.09
- platelet count · score 0.08
- breast carcinoma · score 0.07
- uric acid measurement · score 0.07
- mathematical ability · score 0.07
- diastolic blood pressure · score 0.06
- systemic juvenile idiopathic arthritis · score 0.01
- Abnormal sperm morphology · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BUI4-F1 | alphafold | PREDICTED | 89.03 | — |
Amino-acid sequence (534 residues)
MTQAEIKLCS LLLQEHFGEI VEKIGVHLIR TGSQPLRVIA HDTGTSLDQV KKALCVLVQH NLVSYQVHKR GVVEYEAQCS RVLRMLRYPR YIYTTKTLYS DTGELIVEEL LLNGKLTMSA VVKKVADRLT ETMEDGKTMD YAEVSNTFVR LADTHFVQRC PSVPTTENSD PGPPPPAPTL VINEKDMYLV PKLSLIGKGK RRRSSDEDAA GEPKAKRPKY TTDNKEPIPD DGIYWQANLD RFHQHFRDQA IVSAVANRMD QTSSEIVRTM LRMSEITTSS SAPFTQPLSS NEIFRSLPVG YNISKQVLDQ YLTLLADDPL EFVGKSGDSG GGMYVINLHK ALASLATATL ESVVQERFGS RCARIFRLVL QKKHIEQKQV EDFAMIPAKE AKDMLYKMLS ENFMSLQEIP KTPDHAPSRT FYLYTVNILS AARMLLHRCY KSIANLIERR QFETKENKRL LEKSQRVEAI IASMQATGAE EAQLQEIEEM ITAPERQQLE TLKRNVNKLD ASEIQVDETI FLLESYIECT MKRQ
Explore DNA-directed RNA polymerase III subunit RPC3 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets