About Heterogeneous nuclear ribonucleoprotein U-like protein 1
Heterogeneous nuclear ribonucleoprotein U-like protein 1 (HNRNPUL1) is a protein
from Homo sapiens identified by UniProt accession
Q9BUJ2, 856 residues long.
MolForge cross-references it against 0 known binders and
58 disease associations.
Target properties
| Protein name | Heterogeneous nuclear ribonucleoprotein U-like protein 1 |
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| UniProt accession | Q9BUJ2 |
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| Gene | HNRNPUL1 |
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| Organism | Homo sapiens |
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| Length | 856 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (58)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.52
- mean corpuscular hemoglobin concentration · score 0.20
- mean corpuscular volume · score 0.20
- platelet count · score 0.17
- coronary artery disease · score 0.16
- chronic lymphocytic leukemia · score 0.15
- mean corpuscular hemoglobin · score 0.14
- serum gamma-glutamyl transferase measurement · score 0.13
- IGA glomerulonephritis · score 0.12
- apolipoprotein A 1 measurement · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BUJ2-F1 | alphafold | PREDICTED | 66.39 | — |
Amino-acid sequence (856 residues)
MDVRRLKVNE LREELQRRGL DTRGLKAELA ERLQAALEAE EPDDERELDA DDEPGRPGHI NEEVETEGGS ELEGTAQPPP PGLQPHAEPG GYSGPDGHYA MDNITRQNQF YDTQVIKQEN ESGYERRPLE MEQQQAYRPE MKTEMKQGAP TSFLPPEASQ LKPDRQQFQS RKRPYEENRG RGYFEHREDR RGRSPQPPAE EDEDDFDDTL VAIDTYNCDL HFKVARDRSS GYPLTIEGFA YLWSGARASY GVRRGRVCFE MKINEEISVK HLPSTEPDPH VVRIGWSLDS CSTQLGEEPF SYGYGGTGKK STNSRFENYG DKFAENDVIG CFADFECGND VELSFTKNGK WMGIAFRIQK EALGGQALYP HVLVKNCAVE FNFGQRAEPY CSVLPGFTFI QHLPLSERIR GTVGPKSKAE CEILMMVGLP AAGKTTWAIK HAASNPSKKY NILGTNAIMD KMRVMGLRRQ RNYAGRWDVL IQQATQCLNR LIQIAARKKR NYILDQTNVY GSAQRRKMRP FEGFQRKAIV ICPTDEDLKD RTIKRTDEEG KDVPDHAVLE MKANFTLPDV GDFLDEVLFI ELQREEADKL VRQYNEEGRK AGPPPEKRFD NRGGGGFRGR GGGGGFQRYE NRGPPGGNRG GFQNRGGGSG GGGNYRGGFN RSGGGGYSQN RWGNNNRDNN NSNNRGSYNR APQQQPPPQQ PPPPQPPPQQ PPPPPSYSPA RNPPGASTYN KNSNIPGSSA NTSTPTVSSY SPPQPSYSQP PYNQGGYSQG YTAPPPPPPP PPAYNYGSYG GYNPAPYTPP PPPTAQTYPQ PSYNQYQQYA QQWNQYYQNQ GQWPPYYGNY DYGSYSGNTQ GGTSTQ
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