Glucose-6-phosphatase 3 (G6PC3)

About Glucose-6-phosphatase 3

Glucose-6-phosphatase 3 (G6PC3) is a protein from Homo sapiens identified by UniProt accession Q9BUM1, 346 residues long. MolForge cross-references it against 0 known binders and 155 disease associations.

Target properties

Protein name	Glucose-6-phosphatase 3
UniProt accession	Q9BUM1
Gene	G6PC3
Organism	Homo sapiens
Length	346 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (155)

Diseases linked to this target (Open Targets).

autosomal recessive severe congenital neutropenia due to G6PC3 deficiency · score 0.85
severe congenital neutropenia · score 0.74
constitutional neutropenia · score 0.47
neurodegenerative disease · score 0.19
genetic disorder · score 0.18
body height · score 0.15
heel bone mineral density · score 0.12
pulse pressure measurement · score 0.11
bone density · score 0.10
bone quantitative ultrasound measurement · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BUM1-F1	alphafold	PREDICTED	92.74	—

Amino-acid sequence (346 residues)

MESTLGAGIV IAEALQNQLA WLENVWLWIT FLGDPKILFL FYFPAAYYAS RRVGIAVLWI SLITEWLNLI FKWFLFGDRP FWWVHESGYY SQAPAQVHQF PSSCETGPGS PSGHCMITGA ALWPIMTALS SQVATRARSR WVRVMPSLAY CTFLLAVGLS RIFILAHFPH QVLAGLITGA VLGWLMTPRV PMERELSFYG LTALALMLGT SLIYWTLFTL GLDLSWSISL AFKWCERPEW IHVDSRPFAS LSRDSGAALG LGIALHSPCY AQVRRAQLGN GQKIACLVLA MGLLGPLDWL GHPPQISLFY IFNFLKYTLW PCLVLALVPW AVHMFSAQEA PPIHSS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards