About Coiled-coil domain-containing protein 28B
Coiled-coil domain-containing protein 28B (CCDC28B) is a protein
from Homo sapiens identified by UniProt accession
Q9BUN5, 200 residues long.
MolForge cross-references it against 0 known binders and
34 disease associations.
Target properties
| Protein name | Coiled-coil domain-containing protein 28B |
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| UniProt accession | Q9BUN5 |
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| Gene | CCDC28B |
|---|
| Organism | Homo sapiens |
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| Length | 200 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (34)
Diseases linked to this target (Open Targets).
- Bardet-Biedl syndrome 1 · score 0.37
- Bardet-Biedl syndrome · score 0.12
- Asperger syndrome · score 0.06
- autism · score 0.05
- Autism · score 0.04
- MODY · score 0.04
- 15q11q13 microduplication syndrome · score 0.04
- severe early-onset obesity-insulin resistance syndrome due to SH2B1 deficiency · score 0.04
- autism spectrum disorder · score 0.04
- diabetes mellitus, permanent neonatal 3 · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BUN5-F1 | alphafold | PREDICTED | 70.03 | — |
Amino-acid sequence (200 residues)
MDDKKKKRSP KPCLAQPAQA PGTLRRVPVP TSHSGSLALG LPHLPSPKQR AKFKRVGKEK CRPVLAGGGS GSAGTPLQHS FLTEVTDVYE MEGGLLNLLN DFHSGRLQAF GKECSFEQLE HVREMQEKLA RLHFSLDVCG EEEDDEEEED GVTEGLPEEQ KKTMADRNLD QLLSNLEDLS NSIQKLHLAE NAEPEEQSAA
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