About Derlin-1
Derlin-1 (DERL1) is a protein
from Homo sapiens identified by UniProt accession
Q9BUN8, 251 residues long.
MolForge cross-references it against 0 known binders and
87 disease associations.
Target properties
| Protein name | Derlin-1 |
|---|
| UniProt accession | Q9BUN8 |
|---|
| Gene | DERL1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 251 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (87)
Diseases linked to this target (Open Targets).
- cystic fibrosis · score 0.46
- mean corpuscular volume · score 0.26
- mean reticulocyte volume · score 0.26
- pancreatic adenocarcinoma · score 0.24
- blood urea nitrogen measurement · score 0.21
- serum urea measurement · score 0.21
- thyroid gland adenocarcinoma · score 0.18
- urinary bladder carcinoma · score 0.09
- neoplasm · score 0.08
- hepatocellular carcinoma · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BUN8-F1 | alphafold | PREDICTED | 80.02 | — |
Amino-acid sequence (251 residues)
MSDIGDWFRS IPAITRYWFA ATVAVPLVGK LGLISPAYLF LWPEAFLYRF QIWRPITATF YFPVGPGTGF LYLVNLYFLY QYSTRLETGA FDGRPADYLF MLLFNWICIV ITGLAMDMQL LMIPLIMSVL YVWAQLNRDM IVSFWFGTRF KACYLPWVIL GFNYIIGGSV INELIGNLVG HLYFFLMFRY PMDLGGRNFL STPQFLYRWL PSRRGGVSGF GVPPASMRRA ADQNGGGGRH NWGQGFRLGD Q
Explore Derlin-1 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets