About Probable ATP-dependent RNA helicase DDX23
Probable ATP-dependent RNA helicase DDX23 (DDX23) is a protein
from Homo sapiens identified by UniProt accession
Q9BUQ8, 820 residues long.
MolForge cross-references it against 0 known binders and
45 disease associations.
Target properties
| Protein name | Probable ATP-dependent RNA helicase DDX23 |
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| UniProt accession | Q9BUQ8 |
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| Gene | DDX23 |
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| Organism | Homo sapiens |
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| Length | 820 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (45)
Diseases linked to this target (Open Targets).
- global developmental delay with speech and behavioral abnormalities · score 0.37
- Neurodevelopmental disorder · score 0.27
- IMAGe syndrome · score 0.27
- bilateral perisylvian polymicrogyria · score 0.27
- Abnormal facial shape · score 0.27
- fetal growth restriction · score 0.27
- Motor delay · score 0.27
- Failure to thrive · score 0.27
- chronic lymphocytic leukemia · score 0.23
- hemoglobin measurement · score 0.21
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BUQ8-F1 | alphafold | PREDICTED | 77.65 | — |
Amino-acid sequence (820 residues)
MAGELADKKD RDASPSKEER KRSRTPDRER DRDRDRKSSP SKDRKRHRSR DRRRGGSRSR SRSRSKSAER ERRHKERERD KERDRNKKDR DRDKDGHRRD KDRKRSSLSP GRGKDFKSRK DRDSKKDEED EHGDKKPKAQ PLSLEELLAK KKAEEEAEAK PKFLSKAERE AEALKRRQQE VEERQRMLEE ERKKRKQFQD LGRKMLEDPQ ERERRERRER MERETNGNED EEGRQKIREE KDKSKELHAI KERYLGGIKK RRRTRHLNDR KFVFEWDASE DTSIDYNPLY KERHQVQLLG RGFIAGIDLK QQKREQSRFY GDLMEKRRTL EEKEQEEARL RKLRKKEAKQ RWDDRHWSQK KLDEMTDRDW RIFREDYSIT TKGGKIPNPI RSWKDSSLPP HILEVIDKCG YKEPTPIQRQ AIPIGLQNRD IIGVAETGSG KTAAFLIPLL VWITTLPKID RIEESDQGPY AIILAPTREL AQQIEEETIK FGKPLGIRTV AVIGGISRED QGFRLRMGCE IVIATPGRLI DVLENRYLVL SRCTYVVLDE ADRMIDMGFE PDVQKILEHM PVSNQKPDTD EAEDPEKMLA NFESGKHKYR QTVMFTATMP PAVERLARSY LRRPAVVYIG SAGKPHERVE QKVFLMSESE KRKKLLAILE QGFDPPIIIF VNQKKGCDVL AKSLEKMGYN ACTLHGGKGQ EQREFALSNL KAGAKDILVA TDVAGRGIDI QDVSMVVNYD MAKNIEDYIH RIGRTGRAGK SGVAITFLTK EDSAVFYELK QAILESPVSS CPPELANHPD AQHKPGTILT KKRREETIFA
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