About Telomerase Cajal body protein 1
Telomerase Cajal body protein 1 (WRAP53) is a protein
from Homo sapiens identified by UniProt accession
Q9BUR4, 548 residues long.
MolForge cross-references it against 0 known binders and
124 disease associations.
Target properties
| Protein name | Telomerase Cajal body protein 1 |
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| UniProt accession | Q9BUR4 |
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| Gene | WRAP53 |
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| Organism | Homo sapiens |
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| Length | 548 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (124)
Diseases linked to this target (Open Targets).
- dyskeratosis congenita · score 0.78
- neurodegenerative disease · score 0.55
- Inherited cancer-predisposing syndrome · score 0.47
- hereditary neoplastic syndrome · score 0.47
- Alzheimer disease · score 0.44
- Parkinson disease · score 0.44
- multiple sclerosis · score 0.44
- lysosomal storage disease · score 0.44
- X-linked severe congenital neutropenia · score 0.37
- sex hormone-binding globulin measurement · score 0.29
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BUR4-F1 | alphafold | PREDICTED | 73.03 | — |
Amino-acid sequence (548 residues)
MKTLETQPLA PDCCPSDQDP APAHPSPHAS PMNKNADSEL MPPPPERGDP PRLSPDPVAG SAVSQELREG DPVSLSTPLE TEFGSPSELS PRIEEQELSE NTSLPAEEAN GSLSEEEANG PELGSGKAME DTSGEPAAED EGDTAWNYSF SQLPRFLSGS WSEFSTQPEN FLKGCKWAPD GSCILTNSAD NILRIYNLPP ELYHEGEQVE YAEMVPVLRM VEGDTIYDYC WYSLMSSAQP DTSYVASSSR ENPIHIWDAF TGELRASFRA YNHLDELTAA HSLCFSPDGS QLFCGFNRTV RVFSTARPGR DCEVRATFAK KQGQSGIISC IAFSPAQPLY ACGSYGRSLG LYAWDDGSPL ALLGGHQGGI THLCFHPDGN RFFSGARKDA ELLCWDLRQS GYPLWSLGRE VTTNQRIYFD LDPTGQFLVS GSTSGAVSVW DTDGPGNDGK PEPVLSFLPQ KDCTNGVSLH PSLPLLATAS GQRVFPEPTE SGDEGEELGL PLLSTRHVHL ECRLQLWWCG GAPDSSIPDD HQGEKGQGGT EGGVGELI
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