About Dehydrogenase/reductase SDR family member 6
Dehydrogenase/reductase SDR family member 6 (BDH2) is a protein
from Homo sapiens identified by UniProt accession
Q9BUT1, 245 residues long.
MolForge cross-references it against 0 known binders and
74 disease associations.
Target properties
| Protein name | Dehydrogenase/reductase SDR family member 6 |
|---|
| UniProt accession | Q9BUT1 |
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| Gene | BDH2 |
|---|
| Organism | Homo sapiens |
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| Length | 245 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (74)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.37
- pulse pressure measurement · score 0.27
- Testicular Germ Cell Tumor · score 0.19
- testicular carcinoma · score 0.16
- type 2 diabetes mellitus · score 0.14
- glomerular filtration rate · score 0.11
- hepatocellular carcinoma · score 0.08
- nonpapillary renal cell carcinoma · score 0.07
- acute myeloid leukemia · score 0.07
- sex hormone-binding globulin measurement · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BUT1-F1 | alphafold | PREDICTED | 97.50 | — |
Amino-acid sequence (245 residues)
MGRLDGKVII LTAAAQGIGQ AAALAFAREG AKVIATDINE SKLQELEKYP GIQTRVLDVT KKKQIDQFAN EVERLDVLFN VAGFVHHGTV LDCEEKDWDF SMNLNVRSMY LMIKAFLPKM LAQKSGNIIN MSSVASSVKG VVNRCVYSTT KAAVIGLTKS VAADFIQQGI RCNCVCPGTV DTPSLQERIQ ARGNPEEARN DFLKRQKTGR FATAEEIAML CVYLASDESA YVTGNPVIID GGWSL
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