GEL complex subunit OPTI (RAB5IF)

About GEL complex subunit OPTI

GEL complex subunit OPTI (RAB5IF) is a protein from Homo sapiens identified by UniProt accession Q9BUV8, 137 residues long. MolForge cross-references it against 0 known binders and 32 disease associations.

Target properties

Protein name	GEL complex subunit OPTI
UniProt accession	Q9BUV8
Gene	RAB5IF
Organism	Homo sapiens
Length	137 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (32)

Diseases linked to this target (Open Targets).

Intellectual disability · score 0.33
Bifid ribs · score 0.33
Rib fusion · score 0.33
Abnormality of the vertebral column · score 0.33
Micrognathia · score 0.33
scoliosis · score 0.33
Hypertelorism · score 0.33
cleft lip · score 0.33
Macrocephaly · score 0.33
Cerebro-facio-thoracic dysplasia · score 0.26

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BUV8-F1	alphafold	PREDICTED	72.00	—

Amino-acid sequence (137 residues)

MSGGRRKEEP PQPQLANGAL KVSVWSKVLR SDAAWEDKDE FLDVIYWFRQ IIAVVLGVIW GVLPLRGFLG IAGFCLINAG VLYLYFSNYL QIDEEEYGGT WELTKEGFMT SFALFMVCVA DSFTTGHLDH LLHCHPL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards