TNF receptor-associated factor 4 (TRAF4)

About TNF receptor-associated factor 4

TNF receptor-associated factor 4 (TRAF4) is a protein from Homo sapiens identified by UniProt accession Q9BUZ4, 470 residues long. MolForge cross-references it against 0 known binders and 158 disease associations.

Target properties

Protein name	TNF receptor-associated factor 4
UniProt accession	Q9BUZ4
Gene	TRAF4
Organism	Homo sapiens
Length	470 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (158)

Diseases linked to this target (Open Targets).

reticulocyte count · score 0.22
Red cell distribution width · score 0.20
mean corpuscular hemoglobin concentration · score 0.17
serum alanine aminotransferase measurement · score 0.16
hemoglobin measurement · score 0.15
reticulocyte measurement · score 0.14
HMG CoA reductase inhibitor use measurement · score 0.14
insomnia measurement · score 0.14
mean corpuscular hemoglobin · score 0.13
cortical thickness · score 0.12

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BUZ4-F1	alphafold	PREDICTED	91.30	—

Amino-acid sequence (470 residues)

MPGFDYKFLE KPKRRLLCPL CGKPMREPVQ VSTCGHRFCD TCLQEFLSEG VFKCPEDQLP LDYAKIYPDP ELEVQVLGLP IRCIHSEEGC RWSGPLRHLQ GHLNTCSFNV IPCPNRCPMK LSRRDLPAHL QHDCPKRRLK CEFCGCDFSG EAYESHEGMC PQESVYCENK CGARMMRRLL AQHATSECPK RTQPCTYCTK EFVFDTIQSH QYQCPRLPVA CPNQCGVGTV AREDLPGHLK DSCNTALVLC PFKDSGCKHR CPKLAMARHV EESVKPHLAM MCALVSRQRQ ELQELRRELE ELSVGSDGVL IWKIGSYGRR LQEAKAKPNL ECFSPAFYTH KYGYKLQVSA FLNGNGSGEG THLSLYIRVL PGAFDNLLEW PFARRVTFSL LDQSDPGLAK PQHVTETFHP DPNWKNFQKP GTWRGSLDES SLGFGYPKFI SHQDIRKRNY VRDDAVFIRA AVELPRKILS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards