About Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase
Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase (ALG12) is a protein
from Homo sapiens identified by UniProt accession
Q9BV10, 488 residues long.
MolForge cross-references it against 0 known binders and
121 disease associations.
Target properties
| Protein name | Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase |
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| UniProt accession | Q9BV10 |
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| Gene | ALG12 |
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| Organism | Homo sapiens |
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| Length | 488 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (121)
Diseases linked to this target (Open Targets).
- ALG12-congenital disorder of glycosylation · score 0.82
- genetic disorder · score 0.41
- congenital disorder of glycosylation type I · score 0.37
- Krabbe disease · score 0.27
- mean platelet volume · score 0.20
- platelet component distribution width · score 0.19
- platelet count · score 0.18
- congenital disorder of glycosylation · score 0.16
- heel bone mineral density · score 0.16
- sex hormone-binding globulin measurement · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BV10-F1 | alphafold | PREDICTED | 93.09 | — |
Amino-acid sequence (488 residues)
MAGKGSSGRR PLLLGLLVAV ATVHLVICPY TKVEESFNLQ ATHDLLYHWQ DLEQYDHLEF PGVVPRTFLG PVVIAVFSSP AVYVLSLLEM SKFYSQLIVR GVLGLGVIFG LWTLQKEVRR HFGAMVATMF CWVTAMQFHL MFYCTRTLPN VLALPVVLLA LAAWLRHEWA RFIWLSAFAI IVFRVELCLF LGLLLLLALG NRKVSVVRAL RHAVPAGILC LGLTVAVDSY FWRQLTWPEG KVLWYNTVLN KSSNWGTSPL LWYFYSALPR GLGCSLLFIP LGLVDRRTHA PTVLALGFMA LYSLLPHKEL RFIIYAFPML NITAARGCSY LLNNYKKSWL YKAGSLLVIG HLVVNAAYSA TALYVSHFNY PGGVAMQRLH QLVPPQTDVL LHIDVAAAQT GVSRFLQVNS AWRYDKREDV QPGTGMLAYT HILMEAAPGL LALYRDTHRV LASVVGTTGV SLNLTQLPPF NVHLQTKLVL LERLPRPS
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