Methylthioribose-1-phosphate isomerase (MRI1)

About Methylthioribose-1-phosphate isomerase

Methylthioribose-1-phosphate isomerase (MRI1) is a protein from Homo sapiens identified by UniProt accession Q9BV20, 369 residues long. MolForge cross-references it against 0 known binders and 42 disease associations.

Target properties

Protein name	Methylthioribose-1-phosphate isomerase
UniProt accession	Q9BV20
Gene	MRI1
Organism	Homo sapiens
Length	369 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (42)

Diseases linked to this target (Open Targets).

Cerebral degeneration · score 0.26
infantile epilepsy syndrome · score 0.26
glycoprotein storage disease · score 0.05
lymphocyte count · score 0.04
monocyte count · score 0.04
neutrophil percentage of leukocytes · score 0.04
leukocyte count · score 0.04
hemoglobin H disease · score 0.04
hemoglobin C-beta-thalassemia syndrome · score 0.04
lymphocyte percentage of leukocytes · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BV20-F1	alphafold	PREDICTED	94.81	—

Amino-acid sequence (369 residues)

MTLEAIRYSR GSLQILDQLL LPKQSRYEAV GSVHQAWEAI RAMKVRGAPA IALVGCLSLA VELQAGAGGP GLAALVAFVR DKLSFLVTAR PTAVNMARAA RDLADVAARE AEREGATEEA VRERVICCTE DMLEKDLRDN RSIGDLGARH LLERVAPSGG KVTVLTHCNT GALATAGYGT ALGVIRSLHS LGRLEHAFCT ETRPYNQGAR LTAFELVYEQ IPATLITDSM VAAAMAHRGV SAVVVGADRV VANGDTANKV GTYQLAIVAK HHGIPFYVAA PSSSCDLRLE TGKEIIIEER PGQELTDVNG VRIAAPGIGV WNPAFDVTPH DLITGGIITE LGVFAPEELR TALTTTISSR DGTLDGPQM

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards