Mitochondrial adenyl nucleotide antiporter SLC25A23 (SLC25A23)

About Mitochondrial adenyl nucleotide antiporter SLC25A23

Mitochondrial adenyl nucleotide antiporter SLC25A23 (SLC25A23) is a protein from Homo sapiens identified by UniProt accession Q9BV35, 468 residues long. MolForge cross-references it against 0 known binders and 26 disease associations.

Target properties

Protein name	Mitochondrial adenyl nucleotide antiporter SLC25A23
UniProt accession	Q9BV35
Gene	SLC25A23
Organism	Homo sapiens
Length	468 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (26)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.28
monocyte count · score 0.11
pentosuria · score 0.05
FRAXF syndrome · score 0.03
primary hyperoxaluria type 3 · score 0.03
medulloblastoma · score 0.02
colorectal cancer · score 0.01
large cell medulloblastoma · score 0.01
oral squamous cell carcinoma · score 0.01
ulcerative colitis · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BV35-F1	alphafold	PREDICTED	78.38	—

Amino-acid sequence (468 residues)

MRGSPGDAER RQRWGRLFEE LDSNKDGRVD VHELRQGLAR LGGGNPDPGA QQGISSEGDA DPDGGLDLEE FSRYLQEREQ RLLLMFHSLD RNQDGHIDVS EIQQSFRALG ISISLEQAEK ILHSMDRDGT MTIDWQEWRD HFLLHSLENV EDVLYFWKHS TVLDIGECLT VPDEFSKQEK LTGMWWKQLV AGAVAGAVSR TGTAPLDRLK VFMQVHASKT NRLNILGGLR SMVLEGGIRS LWRGNGINVL KIAPESAIKF MAYEQIKRAI LGQQETLHVQ ERFVAGSLAG ATAQTIIYPM EVLKTRLTLR RTGQYKGLLD CARRILEREG PRAFYRGYLP NVLGIIPYAG IDLAVYETLK NWWLQQYSHD SADPGILVLL ACGTISSTCG QIASYPLALV RTRMQAQASI EGGPQLSMLG LLRHILSQEG MRGLYRGIAP NFMKVIPAVS ISYVVYENMK QALGVTSR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards