WD repeat-containing protein 18 (WDR18)

About WD repeat-containing protein 18

WD repeat-containing protein 18 (WDR18) is a protein from Homo sapiens identified by UniProt accession Q9BV38, 432 residues long. MolForge cross-references it against 0 known binders and 14 disease associations.

Target properties

Protein name	WD repeat-containing protein 18
UniProt accession	Q9BV38
Gene	WDR18
Organism	Homo sapiens
Length	432 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (14)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.42
vital capacity · score 0.24
neutrophil count · score 0.06
protein measurement · score 0.04
reticulocyte count · score 0.03
mean platelet volume · score 0.03
reticulocyte measurement · score 0.03
mitochondrial DNA measurement · score 0.02
hepatocellular carcinoma · score 0.02
neoplasm · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BV38-F1	alphafold	PREDICTED	85.48	—

Amino-acid sequence (432 residues)

MAAPMEVAVC TDSAAPMWSC IVWELHSGAN LLTYRGGQAG PRGLALLNGE YLLAAQLGKN YISAWELQRK DQLQQKIMCP GPVTCLTASP NGLYVLAGVA ESIHLWEVST GNLLVILSRH YQDVSCLQFT GDSSHFISGG KDCLVLVWSL CSVLQADPSR IPAPRHVWSH HALPITDLHC GFGGPLARVA TSSLDQTVKL WEVSSGELLL SVLFDVSIMA VTMDLAEHHM FCGGSEGSIF QVDLFTWPGQ RERSFHPEQD AGKVFKGHRN QVTCLSVSTD GSVLLSGSHD ETVRLWDVQS KQCIRTVALK GPVTNAAILL APVSMLSSDF RPSLPLPHFN KHLLGAEHGD EPRHGGLTLR LGLHQQGSEP SYLDRTEQLQ AVLCSTMEKS VLGGQDQLRV RVTELEDEVR NLRKINRDLF DFSTRFITRP AK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards