About tRNA (guanine(6)-N(2))-methyltransferase THUMP3
tRNA (guanine(6)-N(2))-methyltransferase THUMP3 (THUMPD3) is a protein
from Homo sapiens identified by UniProt accession
Q9BV44, 507 residues long.
MolForge cross-references it against 0 known binders and
42 disease associations.
Target properties
| Protein name | tRNA (guanine(6)-N(2))-methyltransferase THUMP3 |
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| UniProt accession | Q9BV44 |
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| Gene | THUMPD3 |
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| Organism | Homo sapiens |
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| Length | 507 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BV44-F1 | alphafold | PREDICTED | 78.58 | — |
Amino-acid sequence (507 residues)
MCDIEEATNQ LLDVNLHENQ KSVQVTESDL GSESELLVTI GATVPTGFEQ TAADEVREKL GSSCKISRDR GKIYFVISVE SLAQVHCLRS VDNLFVVVQE FQDYQFKQTK EEVLKDFEDL AGKLPWSNPL KVWKINASFK KKKAKRKKIN QNSSKEKINN GQEVKIDQRN VKKEFTSHAL DSHILDYYEN PAIKEDVSTL IGDDLASCKD ETDESSKEET EPQVLKFRVT CNRAGEKHCF TSNEAARDFG GAVQDYFKWK ADMTNFDVEV LLNIHDNEVI VGIALTEESL HRRNITHFGP TTLRSTLAYG MLRLCDPLPY DIIVDPMCGT GAIPIEGATE WSDCFHIAGD NNPLAVNRAA NNIASLLTKS QIKEGKPSWG LPIDAVQWDI CNLPLRTGSV DIIVTDLPFG KRMGSKKRNW NLYPACLREM SRVCTPTTGR AVLLTQDTKC FTKALSGMRH VWRKVDTVWV NVGGLRAAVY VLIRTPQAFV HPSEQDGERG TLWQCKE
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