About ER degradation-enhancing alpha-mannosidase-like protein 2
ER degradation-enhancing alpha-mannosidase-like protein 2 (EDEM2) is a protein
from Homo sapiens identified by UniProt accession
Q9BV94, 578 residues long.
MolForge cross-references it against 0 known binders and
81 disease associations.
Target properties
| Protein name | ER degradation-enhancing alpha-mannosidase-like protein 2 |
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| UniProt accession | Q9BV94 |
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| Gene | EDEM2 |
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| Organism | Homo sapiens |
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| Length | 578 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (81)
Diseases linked to this target (Open Targets).
- COVID-19 · score 0.37
- alkaline phosphatase measurement · score 0.23
- birth weight · score 0.18
- apolipoprotein A 1 measurement · score 0.15
- protein C measurement · score 0.15
- creatinine measurement · score 0.13
- vital capacity · score 0.12
- high density lipoprotein cholesterol measurement · score 0.12
- maturity-onset diabetes of the young · score 0.11
- MODY · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BV94-F1 | alphafold | PREDICTED | 85.40 | — |
Amino-acid sequence (578 residues)
MPFRLLIPLG LLCALLPQHH GAPGPDGSAP DPAHYRERVK AMFYHAYDSY LENAFPFDEL RPLTCDGHDT WGSFSLTLID ALDTLLILGN VSEFQRVVEV LQDSVDFDID VNASVFETNI RVVGGLLSAH LLSKKAGVEV EAGWPCSGPL LRMAEEAARK LLPAFQTPTG MPYGTVNLLH GVNPGETPVT CTAGIGTFIV EFATLSSLTG DPVFEDVARV ALMRLWESRS DIGLVGNHID VLTGKWVAQD AGIGAGVDSY FEYLVKGAIL LQDKKLMAMF LEYNKAIRNY TRFDDWYLWV QMYKGTVSMP VFQSLEAYWP GLQSLIGDID NAMRTFLNYY TVWKQFGGLP EFYNIPQGYT VEKREGYPLR PELIESAMYL YRATGDPTLL ELGRDAVESI EKISKVECGF ATIKDLRDHK LDNRMESFFL AETVKYLYLL FDPTNFIHNN GSTFDAVITP YGECILGAGG YIFNTEAHPI DPAALHCCQR LKEEQWEVED LMREFYSLKR SRSKFQKNTV SSGPWEPPAR PGTLFSPENH DQARERKPAK QKVPLLSCPS QPFTSKLALL GQVFLDSS
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