Tubulin beta-2B chain (TUBB2B)

About Tubulin beta-2B chain

Tubulin beta-2B chain (TUBB2B) is a protein from Homo sapiens identified by UniProt accession Q9BVA1, 445 residues long. MolForge cross-references it against 0 known binders and 563 disease associations.

Target properties

Protein name	Tubulin beta-2B chain
UniProt accession	Q9BVA1
Gene	TUBB2B
Organism	Homo sapiens
Length	445 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (563)

Diseases linked to this target (Open Targets).

complex cortical dysplasia with other brain malformations 7 · score 0.82
Polymicrogyria due to TUBB2B mutation · score 0.80
breast carcinoma · score 0.61
non-small cell lung carcinoma · score 0.61
breast cancer · score 0.61
neoplasm · score 0.61
breast neoplasm · score 0.60
gout · score 0.59
acute lymphoblastic leukemia · score 0.59
Hodgkins lymphoma · score 0.59

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BVA1-F1	alphafold	PREDICTED	91.97	—

Amino-acid sequence (445 residues)

MREIVHIQAG QCGNQIGAKF WEVISDEHGI DPTGSYHGDS DLQLERINVY YNEATGNKYV PRAILVDLEP GTMDSVRSGP FGQIFRPDNF VFGQSGAGNN WAKGHYTEGA ELVDSVLDVV RKESESCDCL QGFQLTHSLG GGTGSGMGTL LISKIREEYP DRIMNTFSVM PSPKVSDTVV EPYNATLSVH QLVENTDETY CIDNEALYDI CFRTLKLTTP TYGDLNHLVS ATMSGVTTCL RFPGQLNADL RKLAVNMVPF PRLHFFMPGF APLTSRGSQQ YRALTVPELT QQMFDSKNMM AACDPRHGRY LTVAAIFRGR MSMKEVDEQM LNVQNKNSSY FVEWIPNNVK TAVCDIPPRG LKMSATFIGN STAIQELFKR ISEQFTAMFR RKAFLHWYTG EGMDEMEFTE AESNMNDLVS EYQQYQDATA DEQGEFEEEE GEDEA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards